Approaches to Improve bioavailability and oral absorption of low water-soluble drug by self- emulsifying drug delivery system

Self-emulsifying drug delivery system (SEDDS), a type of lipid-based technology which are isotropic mixtures oil, surfactant, solvent, and co-solvents generated by the activity liquid or solid self-emulsifying ingredients onto powders. It shown interest in recently for enhancement solubility bioavailability poorly water-soluble drugs (BCS-II). With novelty research this field, novel Excipients have been design with properties enhances solubility, Bioavailabity oral absorption to achieving target response. systems (SEDDS) emerged as an insightful approach delivering highly hydrophobic entities enhance their bioavailability. SEDDS increase addition improving soluble number additional potential pathways, such avoiding hepatic first-pass effect, blocking P-gp efflux, overcoming resistance metabolism cytochrome P450 family enzymes gut liver. Conventional were developed form owned numerous overcome like low stability loading efficiency, fewer choices dosage forms irreversible precipitation excipients. To address these curbs solid-SEDDS (S-SEDDS) was introduced efficient strategy that combined advantages increased stability, portability patient compliance along substantial improvement This review highlights parts SEDDS, characterization evaluation. Which completely summarized via different techniques.